Impact of acute and chronic graft-versus-host disease on human B-cell generation and replication.

نویسندگان

  • Salomé Glauzy
  • Juliette Soret
  • Isabelle Fournier
  • Corinne Douay
  • Hélène Moins-Teisserenc
  • Régis Peffault de Latour
  • Guitta Maki
  • Marie Robin
  • Gérard Socié
  • Antoine Toubert
  • Emmanuel Clave
چکیده

Using B-cell rearrangement excision circle measurements, we analyzed B-cell reconstitution in a cohort of 243 patients who underwent allogeneic stem cell transplantation. Acute and chronic graft-versus-host disease (aGVHD and cGVHD, respectively) transiently increased B-cell replication but decreased overall B-cell neogenesis with a clear difference in terms of kinetics. Moreover, the impact of aGVHD in the absence of cGVHD was transient, recovering at month 6 similar values as in patients who did not suffer from GVHD. Conversely, impact of cGVHD at month 12 in multivariate analysis was independent of the previous aGVHD effect on B-cell output. Finally, we showed in patients affected with cGVHD a higher B-cell division rate that correlates with an elevated BAFF/CD19(+) B-cell ratio, supporting a B-cell hyperactivation state in vivo.

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عنوان ژورنال:
  • Blood

دوره 124 15  شماره 

صفحات  -

تاریخ انتشار 2014